江西发现一例血型新基因突变更新全球血型基因数据库

\u003cdiv class=\"rich_media_content\"\u003e\u003c!--NO_AD_ERROR_2--\u003e\u003cp\u003e　　中新社南昌4月24日电 (记者吴鹏泉)江西省南昌市中心血站输血研究室主任徐晶24日告诉记者，该血站发现一例血型新基因突变，更新全球人类血型基因数据库。\u003c!--NO_AD_0--\u003e\u003c!--EOP_0--\u003e\u003c/p\u003e\u003c!--PARAGRAPH_0--\u003e\n\u003cp\u003e　　据介绍，南昌市中心血站输血研究室申报的\u003c!--VERTICAL_CARD_BEGIN_0--\u003eABO基因启动子区域\u003c!--VERTICAL_CARD_END_0--\u003e关键位点c.1-66G\u0026gt;T单碱基突变，被全球权威核酸序列数据库“GenBank”收录，编号为PZ293347。\u003c!--NO_AD_1--\u003e\u003c!--EOP_1--\u003e\u003c/p\u003e\u003c!--PARAGRAPH_1--\u003e\n\u003cp\u003e　　据了解，该研究室在鉴定献血者血型时发现实验结果异常，于是利用\u003c!--VERTICAL_CARD_BEGIN_1--\u003e三代长读长基因测序\u003c!--VERTICAL_CARD_END_1--\u003e技术，首次发现ABO基因启动子区域关键位点c.1-66G\u0026gt;T单碱基突变，确证其为\u003c!--VERTICAL_CARD_BEGIN_2--\u003eA3亚型\u003c!--VERTICAL_CARD_END_2--\u003e的遗传基础。\u003c!--NO_AD_2--\u003e\u003c!--EOP_2--\u003e\u003c/p\u003e\u003c!--PARAGRAPH_2--\u003e\n\u003cp\u003e　　徐晶表示，此次研究将ABO亚型的分子生物学证据由传统编码区延伸至调控区，实质性拓展了A亚型的遗传谱系，并开创性揭示启动子变异在血型抗原表达梯度调控中的决定性作用，推动血型分子机制研究迈入“\u003c!--VERTICAL_CARD_BEGIN_3--\u003e表观遗传调控\u003c!--VERTICAL_CARD_END_3--\u003e”新范式。\u003c!--NO_AD_3--\u003e\u003c!--EOP_3--\u003e\u003c/p\u003e\u003c!--PARAGRAPH_3--\u003e\n\u003cp\u003e　　血型新基因突变的发现，不仅刷新了人类对血型基因的科学认知，还为临床精准输血筑牢安全防线。徐晶说，相关成果可为疑难血型鉴定、稀有血型库建设、\u003c!--SECURE_LINK_BEGIN_0--\u003e造血干细胞移植\u003c!--SECURE_LINK_END_0--\u003e配型及产前血型预测等临床场景提供精准分子诊断靶点，提升输血相容性评估的预见性与安全性。(完)\u003c!--NO_AD_4--\u003e\u003c!--EOP_4--\u003e\u003c/p\u003e\u003c!--PARAGRAPH_4--\u003e\u003cstyle\u003e.rich_media_content{--news-tabel-th-night-color: #444444;--news-font-day-color: #333;--news-font-night-color: #d9d9d9;--news-bottom-distance: 22px}.rich_media_content p:not([data-exeditor-arbitrary-box=image-box]){letter-spacing:.5px;line-height:30px;margin-bottom:var(--news-bottom-distance);word-wrap:break-word}.rich_media_content .qn-editor-copy p:not([data-exeditor-arbitrary-box=image-box]){letter-spacing:unset;line-height:unset;margin-bottom:unset;word-wrap:unset}.rich_media_content{color:var(--news-font-day-color);font-size:18px}@media(prefers-color-scheme:dark){body:not([data-weui-theme=light]):not([dark-mode-disable=true]) .rich_media_content p:not([data-exeditor-arbitrary-box=image-box]){letter-spacing:.5px;line-height:30px;margin-bottom:var(--news-bottom-distance);word-wrap:break-word}body:not([data-weui-theme=light]):not([dark-mode-disable=true]) .rich_media_content .qn-editor-copy p:not([data-exeditor-arbitrary-box=image-box]):not(.qn-editor-copy){letter-spacing:unset;line-height:unset;margin-bottom:unset;word-wrap:unset}body:not([data-weui-theme=light]):not([dark-mode-disable=true]) .rich_media_content{color:var(--news-font-night-color)}}.data_color_scheme_dark .rich_media_content p:not([data-exeditor-arbitrary-box=image-box]){letter-spacing:.5px;line-height:30px;margin-bottom:var(--news-bottom-distance);word-wrap:break-word}.data_color_scheme_dark .rich_media_content .qn-editor-copy p:not([data-exeditor-arbitrary-box=image-box]){letter-spacing:unset;line-height:unset;margin-bottom:unset;word-wrap:unset}.data_color_scheme_dark .rich_media_content{color:var(--news-font-night-color)}.data_color_scheme_dark .rich_media_content{font-size:18px}.rich_media_content p[data-exeditor-arbitrary-box=image-box]{margin-bottom:11px}.rich_media_content\u003ediv:not(.qnt-video),.rich_media_content\u003esection{margin-bottom:var(--news-bottom-distance)}.rich_media_content hr{margin-bottom:var(--news-bottom-distance)}.rich_media_content .link_list{margin:0;margin-top:20px;min-height:0!important}.rich_media_content blockquote{background:#f9f9f9;border-left:6px solid #ccc;margin:1.5em 10px;padding:.5em 10px}.rich_media_content blockquote p{margin-bottom:0!important}.data_color_scheme_dark .rich_media_content blockquote{background:#323232}@media(prefers-color-scheme:dark){body:not([data-weui-theme=light]):not([dark-mode-disable=true]) .rich_media_content blockquote{background:#323232}}.rich_media_content ol[data-ex-list]{--ol-start: 1;--ol-list-style-type: decimal;list-style-type:none;counter-reset:olCounter calc(var(--ol-start,1) - 1);position:relative}.rich_media_content ol[data-ex-list]\u003eli\u003e:first-child::before{content:counter(olCounter,var(--ol-list-style-type)) '. 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江西发现一例血型新基因突变 更新全球血型基因数据库

江西发现一例血型新基因突变 更新全球血型基因数据库

江西发现一例血型新基因突变更新全球血型基因数据库

江西发现一例血型新基因突变更新全球血型基因数据库